about
Cathepsin H is an additional convertase of pro-granzyme BGenetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor proteinMutations in LRPAP1 are associated with severe myopia in humansCell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progressionCathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infectionCD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survivalCathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expressionProfiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in miceDegradation of oxidized proteins in mammalian cells.An open source protein gel documentation system for proteome analyses.A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosisSynergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in miceDisrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.Cathepsin L is required for endothelial progenitor cell-induced neovascularization.The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.Distinct roles for cysteine cathepsin genes in multistage tumorigenesisCystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.Cathepsin B & L are not required for ebola virus replicationCathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor.Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells.Toward computer-based cleavage site prediction of cysteine endopeptidases.Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer ProgressionNeutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROSDifferential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cellsCaspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.Emerging roles of cysteine cathepsins in disease and their potential as drug targets.Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expressionCathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histonesCathepsin C is a tissue-specific regulator of squamous carcinogenesis.Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies.Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Thomas Reinheckel
@ast
Thomas Reinheckel
@en
Thomas Reinheckel
@es
Thomas Reinheckel
@nl
type
label
Thomas Reinheckel
@ast
Thomas Reinheckel
@en
Thomas Reinheckel
@es
Thomas Reinheckel
@nl
prefLabel
Thomas Reinheckel
@ast
Thomas Reinheckel
@en
Thomas Reinheckel
@es
Thomas Reinheckel
@nl
P214
P106
P214
P31
P496
0000-0001-9866-9105
P735
P7859
viaf-42658273