about
PML regulates p53 acetylation and premature senescence induced by oncogenic RasDual phosphorylation controls Cdc25 phosphatases and mitotic entryInvolvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductasePhosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptorCrystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reactionX-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenaseCrystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal sideStructural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenaseInitiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinaseMass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductaseBinding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences.Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes.A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity.Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.Nitric oxide-induced cellular stress and p53 activation in chronic inflammationBlockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells.Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells.Pigment epithelium-derived factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate cancer cells.N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties.DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy.Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen.RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy.Development of a monoclonal antibody-based ELISA system for glyceraldehyde-derived advanced glycation end products.Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System.DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice.Laminin receptor mediates anti-inflammatory and anti-thrombogenic effects of pigment epithelium-derived factor in myeloma cells.Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1.Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells.An improved anion-exchange high-performance liquid chromatography method for measuring oxidized form of LDLs in human plasma.Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor.TAP-independent presentation of CTL epitopes by Trojan antigens.Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor.Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE.Phosphorylation site interdependence of human p53 post-translational modifications in response to stress.The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice.Involvement of metals in enzymatic and nonenzymatic decomposition of C-terminal alpha-hydroxyglycine to amide: an implication for the catalytic role of enzyme-bound zinc in the peptidylamidoglycolate lyase reaction.Methylglyoxal-derived hydroimidazolone-1 evokes inflammatory reactions in endothelial cells via an interaction with receptor for advanced glycation end products.A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Yuichiro Higashimoto
@ast
Yuichiro Higashimoto
@en
Yuichiro Higashimoto
@es
Yuichiro Higashimoto
@nl
type
label
Yuichiro Higashimoto
@ast
Yuichiro Higashimoto
@en
Yuichiro Higashimoto
@es
Yuichiro Higashimoto
@nl
prefLabel
Yuichiro Higashimoto
@ast
Yuichiro Higashimoto
@en
Yuichiro Higashimoto
@es
Yuichiro Higashimoto
@nl
P106
P1153
35445386900
P31
P496
0000-0003-1382-8598