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Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosisStructure of Enterococcus faecium l , d -Transpeptidase Acylated by Ertapenem Provides Insight into the Inactivation MechanismCharacterization of CrgA, a new partner of the Mycobacterium tuberculosis peptidoglycan polymerization complexesKinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activityRapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.Crystallization and preliminary X-ray analysis of Weissella viridescens FemX UDP-MurNAc-pentapeptide:l-alanine ligase.Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes.The CroRS two-component regulatory system is required for intrinsic beta-lactam resistance in Enterococcus faecalis.Aslfm, the D-aspartate ligase responsible for the addition of D-aspartic acid onto the peptidoglycan precursor of Enterococcus faecium.Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus.Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis InfectionHydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif.Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faeciumMethicillin-Susceptible, Vancomycin-Resistant Staphylococcus aureus, BrazilRole of class A penicillin-binding proteins in PBP5-mediated beta-lactam resistance in Enterococcus faecalisIdiosyncratic features in tRNAs participating in bacterial cell wall synthesis.Acyl acceptor recognition by Enterococcus faecium L,D-transpeptidase Ldtfm.In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli.Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetalesβ-Lactamase inhibition by avibactam in Mycobacterium abscessus.Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site.Cloning, purification, crystallization and preliminary crystallographic analysis of a penicillin-binding protein homologue from Pyrococcus abyssi.Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium.[Efficient combination of clavulanate and beta-lactam antibiotics against extensively drug-resistant M. tuberculosis].Characterization of broad-spectrum Mycobacterium abscessus class A β-lactamase.Synthesis of the L-alanyl-L-alanine cross-bridge of Enterococcus faecalis peptidoglycan.Inhibition of β-lactamases of mycobacteria by avibactam and clavulanate.Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of L,D-Transpeptidase LdtMt1 of Mycobacterium tuberculosis and the Stability toward Hydrolysis by β-Lactamase BlaC.Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteinsFighting resistant tuberculosis with old compounds: the carbapenem paradigmUnexpected Inhibition of Peptidoglycan LD-Transpeptidase fromEnterococcus faeciumby the β-Lactam ImipenemCrystal Structure of a Novel β-Lactam-insensitive Peptidoglycan TranspeptidaseTryptophan Fluorescence Quenching in β-Lactam-Interacting Proteins Is Modulated by the Structure of Intermediates and Final Products of the Acylation Reaction
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jean-Emmanuel Hugonnet
@ast
Jean-Emmanuel Hugonnet
@en
Jean-Emmanuel Hugonnet
@es
Jean-Emmanuel Hugonnet
@nl
type
label
Jean-Emmanuel Hugonnet
@ast
Jean-Emmanuel Hugonnet
@en
Jean-Emmanuel Hugonnet
@es
Jean-Emmanuel Hugonnet
@nl
prefLabel
Jean-Emmanuel Hugonnet
@ast
Jean-Emmanuel Hugonnet
@en
Jean-Emmanuel Hugonnet
@es
Jean-Emmanuel Hugonnet
@nl
P106
P31
P496
0000-0003-4150-0944