Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesOverview of the biology of type I interferonsDouble Roles of Macrophages in Human Neuroimmune Diseases and Their Animal ModelsImmunomodulatory functions of type I interferonsThe regulation of inflammation by interferons and their STATsDifferential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infectionsRegulation of type I interferon responsesRole of microglia in CNS autoimmunityEndogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemiaExacerbated innate host response to SARS-CoV in aged non-human primatesA herpes simplex virus-derived replicative vector expressing LIF limits experimental demyelinating disease and modulates autoimmunityInflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple SclerosisThe mechanism of action of interferon-β in relapsing multiple sclerosisType I interferon is selectively required by dendritic cells for immune rejection of tumorsA type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosisType I interferon: friend or foe?Immune heterogeneity in neuroinflammation: dendritic cells in the brainLaquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunityIL7Rα expression and upregulation by IFNβ in dendritic cell subsets is haplotype-dependentCooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cellsElevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillationsAmelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by photobiomodulation induced by 670 nm lightCharacterization of the interferon-producing cell in mice infected with Listeria monocytogenesType I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection.Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma.IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous systemImmunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis.Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease.Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammationT helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.Type I interferon signals control Theiler's virus infection site, cellular infiltration and T cell stimulation in the CNS.Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity.Interferon-β exacerbates Th17-mediated inflammatory disease.Role of interleukin 10 transcriptional regulation in inflammation and autoimmune diseaseModulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling.Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosisEvolving expectations around early management of multiple sclerosis.MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up.Interferon-β induces hepatocyte growth factor in monocytes of multiple sclerosis patients
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P2860
Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System
description
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2008
@uk
name
Distinct and Nonredundant In V ...... in the Central Nervous System
@en
Distinct and Nonredundant In V ...... in the Central Nervous System
@nl
type
label
Distinct and Nonredundant In V ...... in the Central Nervous System
@en
Distinct and Nonredundant In V ...... in the Central Nervous System
@nl
prefLabel
Distinct and Nonredundant In V ...... in the Central Nervous System
@en
Distinct and Nonredundant In V ...... in the Central Nervous System
@nl
P2093
P50
P1433
P1476
Distinct and Nonredundant In V ...... in the Central Nervous System
@en
P2093
Burkhard Becher
Claudia Detje
Hauke Schmidt
Ilona Gutcher
Jenni Raasch
Jörg Mages
Klaus-Peter Knobeloch
Marco Prinz
Roland Martin
P304
P356
10.1016/J.IMMUNI.2008.03.011
P407
P577
2008-05-01T00:00:00Z