about
Antigene effect in K562 cells of a PEG-conjugated triplex-forming oligonucleotide targeted to the bcr/abl oncogene.Anti-gene effect in live cells of AG motif triplex-forming oligonucleotides containing an increasing number of phosphorothioate linkages.Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies.The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-elementG4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.Role of NF-κB/Snail/RKIP loop in the response of tumor cells to photodynamic therapy.The PDT activity of free and pegylated pheophorbide a against an amelanotic melanoma transplanted in C57/BL6 mice.Anti-gene strategies to down-regulate gene expression in mammalian cells.Spectroscopic and calorimetric investigation on the DNA triplex formed by d(CTCTTCTTTCTTTTCTTTCTTCTC) and d(GAGAAGAAAGA) at acidic pHG4 DNA in ras genes and its potential in cancer therapy.Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: A molecular mechanism involving G4 DNA.Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism.GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation.MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcriptionLipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteinsCharacterization of the DNA triplex formed by d(TGGGTGGGTGGTTGGGTGGG) and a critical R.Y sequence located in the promoter of the murine Ki-ras proto-oncogene.Site-directed inhibition of DNA replication by triple helix formation.G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.Effect of phosphorothioate modifications on the ability of GTn oligodeoxynucleotides to specifically recognize single-stranded DNA-binding proteins and to affect human cancer cellular growth.Sequence-specific DNA-triplex formation at imperfect homopurine-homopyrimidine sequences within a DNA plasmid.Transcription inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide.G-rich oligonucleotide inhibits the binding of a nuclear protein to the Ki-ras promoter and strongly reduces cell growth in human carcinoma pancreatic cells.(A,G)-oligonucleotides form extraordinary stable triple helices with a critical R.Y sequence of the murine c-Ki-ras promoter and inhibit transcription in transfected NIH 3T3 cells.Photosensitizers binding to nucleic acids as anticancer agents.Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells.Repeated sub-optimal photodynamic treatments with pheophorbide a induce an epithelial mesenchymal transition in prostate cancer cells via nitric oxide.HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.Nitric oxide-mediated activity in anti-cancer photodynamic therapy.Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5'-UTR of KRAS oncogene represses translation.Metallation of pentaphyrin with Lu(III) dramatically increases reactive-oxygen species production and cell phototoxicity.Evidence that photoactivated pheophorbide a causes in human cancer cells a photodynamic effect involving lipid peroxidation.Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.Small interfering RNA-mediated silencing of glutathione-S-transferase A1 sensitizes hepatic carcinoma cells to photodynamic therapy with pentaphyrins.The effect of INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions on the structure and biological activity of a G-quadruplex from a critical KRAS G-rich sequence.Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition.Antigene property of PNA conjugated to the nuclear localization signal peptide.Inhibition of gene expression by peptide nucleic acids in cultured cells.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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label
Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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Luigi E Xodo
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P106
P1153
7003368908
P21
P31
P496
0000-0003-3344-7207