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Targets for Ibrutinib Beyond B Cell MalignanciesGene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kineticsPearson correlation analysis of microarray data allows for the identification of genetic targets for early B-cell factor.Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.The Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells.Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia modelCytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.Splice-correction strategies for treatment of X-linked agammaglobulinemia.A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation.The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis.The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiencyGlobal changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fateThe CD53 and CEACAM-1 genes are genetic targets for early B cell factor.Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells.Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.RNA analysis of B cell lines arrested at defined stages of differentiation allows for an approximation of gene expression patterns during B cell development.IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem CellsModeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating CellsCritical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitorsHigh-throughput ChIPmentation: freely scalable, single day ChIPseq data generation from very low cell-numbersThe molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Robert Mansson
@ast
Robert Mansson
@en
Robert Mansson
@es
Robert Mansson
@nl
type
label
Robert Mansson
@ast
Robert Mansson
@en
Robert Mansson
@es
Robert Mansson
@nl
prefLabel
Robert Mansson
@ast
Robert Mansson
@en
Robert Mansson
@es
Robert Mansson
@nl
P106
P31
P496
0000-0003-0738-0328