about
Visualization of bidirectional initiation of chromosomal DNA replication in a human cell free systemPeaks cloaked in the mist: the landscape of mammalian replication originsHow MCM loading and spreading specify eukaryotic DNA replication initiation sitesTopoisomerase II can unlink replicating DNA by precatenane removalReplication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts.Universal temporal profile of replication origin activation in eukaryotesHemicatenanes form upon inhibition of DNA replicationBi-directional replication and random termination.Mechanisms and consequences of replication fork arrest.Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genomeReplication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell linesParadoxes of eukaryotic DNA replication: MCM proteins and the random completion problem.Replication landscape of the human genomeDNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extractsCdc45 is a critical effector of myc-dependent DNA replication stress.From simple bacterial and archaeal replicons to replication N/U-domains.Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations.Site-specific and temporally controlled initiation of DNA replication in a human cell-free systemUse of DNA combing to study DNA replication in Xenopus and human cell-free systems.Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure.Broadening of DNA replication origin usage during metazoan cell differentiationY RNA functions at the initiation step of mammalian chromosomal DNA replication.DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts.Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.Mathematical modelling of eukaryotic DNA replication.Topological analysis of plasmid DNA replication intermediates using two-dimensional agarose gels.Single-molecule, antibody-free fluorescent visualisation of replication tracts along barcoded DNA molecules.The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation.Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regionsDevelopmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regionsDual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.Transition in specification of embryonic metazoan DNA replication originsMechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Olivier Hyrien
@ast
Olivier Hyrien
@en
Olivier Hyrien
@es
Olivier Hyrien
@nl
type
label
Olivier Hyrien
@ast
Olivier Hyrien
@en
Olivier Hyrien
@es
Olivier Hyrien
@nl
prefLabel
Olivier Hyrien
@ast
Olivier Hyrien
@en
Olivier Hyrien
@es
Olivier Hyrien
@nl
P106
P31
P496
0000-0001-8879-675X