about
Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy.CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosisMechanical stress impairs mitosis progression in multi-cellular tumor spheroidsDeep and clear optical imaging of thick inhomogeneous samplesHigh-resolution in-depth imaging of optically cleared thick samples using an adaptive SPIMNuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophyProtein kinase CK2 regulates CDC25B phosphatase activityThe human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane spaceEvaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matricesMonitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid ModelCell cycle control by the CDC25 phosphatasesStudy of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase.Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors.Pharmacological inhibition of aurora-A but not aurora-B impairs interphase microtubule dynamics.3D imaging of the response to CDC25 inhibition in multicellular spheroids.A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 siteSubcellular localisation of human wee1 kinase is regulated during the cell cycle.CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity.Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D.CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar fociCharacterization of the antiproliferative activity of Xylopia aethiopicacdc2 phosphorylation is required for its interaction with cyclin.Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype.Oxygen Partial Pressure Is a Rate-Limiting Parameter for Cell Proliferation in 3D Spheroids Grown in Physioxic Culture Condition.CDC25 phosphatases in cancer cells: key players? Good targets?Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cellsMicrocephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1OPA1 functions in mitochondria and dysfunctions in optic nerve.Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids.Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?Microdevice arrays of high aspect ratio poly(dimethylsiloxane) pillars for the investigation of multicellular tumour spheroid mechanical properties.A versatile sample holder for single plane illumination microscopy.Microtubule cytoskeleton and morphogenesis in the amoebae of the myxomycete Physarum polycephalum.Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors.5-Substituted [1]pyrindine derivatives with antiproliferative activity.NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo: full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro.G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C.CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Bernard Ducommun
@ast
Bernard Ducommun
@en
Bernard Ducommun
@es
Bernard Ducommun
@nl
type
label
Bernard Ducommun
@ast
Bernard Ducommun
@en
Bernard Ducommun
@es
Bernard Ducommun
@nl
prefLabel
Bernard Ducommun
@ast
Bernard Ducommun
@en
Bernard Ducommun
@es
Bernard Ducommun
@nl
P106
P31
P496
0000-0002-7126-8368