about
Rho-stimulated contractility drives the formation of stress fibers and focal adhesionsFocal adhesions, contractility, and signalingRap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularizationRap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly.Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling.Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation.Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.Focal adhesion assembly
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Magdalena Chrzanowska-Wodnicka
@ast
Magdalena Chrzanowska-Wodnicka
@en
Magdalena Chrzanowska-Wodnicka
@es
Magdalena Chrzanowska-Wodnicka
@nl
type
label
Magdalena Chrzanowska-Wodnicka
@ast
Magdalena Chrzanowska-Wodnicka
@en
Magdalena Chrzanowska-Wodnicka
@es
Magdalena Chrzanowska-Wodnicka
@nl
prefLabel
Magdalena Chrzanowska-Wodnicka
@ast
Magdalena Chrzanowska-Wodnicka
@en
Magdalena Chrzanowska-Wodnicka
@es
Magdalena Chrzanowska-Wodnicka
@nl
P106
P1153
6603265090
P21
P31
P496
0000-0003-4182-2126