A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence
about
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web serverAssembly, trafficking and function of gamma-secretasePen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Structural investigation of the C-terminal catalytic fragment of presenilin 1Transmembrane topology and signal peptide prediction using dynamic bayesian networksChanged membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE.Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FADStructural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Toward structural elucidation of the gamma-secretase complex.Molecular genetics of Alzheimer's disease: an update.Presenilins: members of the gamma-secretase quartets, but part-time soloists too.Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.Identification of gamma-secretase inhibitor potency determinants on presenilin.Application of intra-molecular fluorescence complementation in the topology examination of polytopic proteins in living cells.Linear patterns of Alzheimer's disease mutations along alpha-helices of presenilins as a tool for PS-1 model construction.
P2860
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P2860
A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence
description
article
@en
im Mai 2005 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2005
@uk
name
A novel transmembrane topology ...... tal and computational evidence
@en
A novel transmembrane topology ...... tal and computational evidence
@nl
type
label
A novel transmembrane topology ...... tal and computational evidence
@en
A novel transmembrane topology ...... tal and computational evidence
@nl
prefLabel
A novel transmembrane topology ...... tal and computational evidence
@en
A novel transmembrane topology ...... tal and computational evidence
@nl
P1433
P1476
A novel transmembrane topology ...... tal and computational evidence
@en
P2093
Anna Henricson
P304
P356
10.1111/J.1742-4658.2005.04691.X
P407
P577
2005-05-13T00:00:00Z