Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

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im Januar 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 17 July 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

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Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

@en

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

@nl

P1476

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

@en

P2093

Eduardo H G da Cruz

http://www.w3.org/2001/XMLSchema#string

Jakob Roth

http://www.w3.org/2001/XMLSchema#string

Markus Werner

http://www.w3.org/2001/XMLSchema#string

Marta C Marques

http://www.w3.org/2001/XMLSchema#string

Oliver Werz

http://www.w3.org/2001/XMLSchema#string

Padma Akkapeddi

http://www.w3.org/2001/XMLSchema#string

Susana A Lobo

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P2860

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

Relating protein pharmacology by ligand chemistry

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.

SuperPred: update on drug classification and target prediction

The re-emergence of natural products for drug discovery in the genomics era.

Natural Products as Sources of New Drugs from 1981 to 2014.

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

Chemically Advanced Template Search (CATS) for Scaffold-Hopping and Prospective Target Prediction for 'Orphan' Molecules.

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1

P304

6899-6903

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P31

scholarly article

P356

10.1039/C8SC02634C

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Francisco Corzana

Tiago Rodrigues

Gonçalo J. L. Bernardes

Andreas Koeberle

Eufrânio N da Silva Júnior

P577

2018-07-17T00:00:00Z

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P698

30310622

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P921

allosteric inhibitor

general chemistry

P932

6138237

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