about
Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells.TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill.DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer.Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effectsBoth human and mouse mesenchymal stem cells promote breast cancer metastasis.TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors.Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells.Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells.A non-apoptotic role for caspase-9 in muscle differentiation.MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release.In situ trapping of initiator caspases reveals intermediate surprises.Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells.AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression.Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells.Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis.Development of a FACS-based Smac/DIABLO release assay to monitor individual drug responses and to pave the way towards patient-tailored therapies.Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment.Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release
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description
researcher ORCID ID = 0000-0002-4295-0341
@en
wetenschapper
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name
Andrea Mohr
@ast
Andrea Mohr
@en
Andrea Mohr
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Andrea Mohr
@nl
type
label
Andrea Mohr
@ast
Andrea Mohr
@en
Andrea Mohr
@es
Andrea Mohr
@nl
prefLabel
Andrea Mohr
@ast
Andrea Mohr
@en
Andrea Mohr
@es
Andrea Mohr
@nl
P108
P106
P31
P496
0000-0002-4295-0341