about
Evaluation of some newer matrix metalloproteinasesExome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemiaHuman Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genesFunctional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patientsHuman Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissuesAutophagy is essential for mouse sense of balanceInterruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotypePredict7, a program for protein structure prediction.Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma.Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization.Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis.Deubiquitinases in cancer: new functions and therapeutic options.Reprogramming aging and progeria.Metabolic Control of Longevity.Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.A functional link between the tumour suppressors ARF and p33ING1.High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus.A gene homologous to topoisomerase II in African swine fever virus.Mapping and sequence of the gene coding for protein p72, the major capsid protein of African swine fever virus.Deubiquitination in cancer stem cells.Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.Premature aging in mice activates a systemic metabolic response involving autophagy induction.Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.A conserved splicing mechanism of the LMNA gene controls premature aging.Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.Loss of the Deubiquitinase USP36 Destabilizes the RNA Helicase DHX33 and Causes Preimplantation Lethality in Mice.Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging.NF-κB signaling as a driver of ageing.From immature lamin to premature aging: molecular pathways and therapeutic opportunities.
P50
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P50
description
researcher ORCID ID = 0000-0002-4688-8266
@en
wetenschapper
@nl
name
Jose M Freije
@ast
Jose M Freije
@en
Jose M Freije
@nl
type
label
Jose M Freije
@ast
Jose M Freije
@en
Jose M Freije
@nl
prefLabel
Jose M Freije
@ast
Jose M Freije
@en
Jose M Freije
@nl
P106
P21
P31
P496
0000-0002-4688-8266