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Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2'-deoxyuridine-5'-monophosphate on ABCC11 in silico modelsStructures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domainTwo different centered monoclinic crystals of the E. coli outer-membrane protein OmpF originate from the same building blockStructuring detergents for extracting and stabilizing functional membrane proteinsA hydrophobic filter confers the cation selectivity of Zygosaccharomyces rouxii plasma-membrane Na+/H+ antiporter.Quantification of Detergents Complexed with Membrane ProteinsCharacterization of a protease-resistant domain of the cytosolic portion of sarcoplasmic reticulum Ca2+-ATPase. Nucleotide- and metal-binding sites.Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.A new method for the reconstitution of membrane proteins into giant unilamellar vesiclesABCG2 transports and transfers heme to albumin through its large extracellular loopUnderstanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoproteinStubborn contaminants: influence of detergents on the purity of the multidrug ABC transporter BmrA.Efficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studiesStructural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.Atomic modelling and systematic mutagenesis identify residues in multiple drug binding sites that are essential for drug resistance in the major Candida transporter Cdr1.Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport.Expression of the sarcoplasmic reticulum Ca(2+)-ATPase in yeast.Targeting the multidrug ABCG2 transporter with flavonoidic inhibitors: in vitro optimization and in vivo validation.Modulators of the human ABCC2: hope from natural sources?Peroxisomal ATP-binding cassette transporters form mainly tetramers.Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.MRP1-dependent Collateral Sensitivity of Multidrug-resistant Cancer Cells: Identifying Selective Modulators Inducing Cellular Glutathione Depletion.Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.Diffraction anisotropy falloff in the direction of the detergent belt for two centered monoclinic crystals of OmpFMethoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein.Overexpression of SERCA1a Ca2+-ATPase in yeast.Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer propertiesBeta subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type protein and identification of a mutation that increases nucleotide binding.Involvement of the cytoplasmic loop L6-7 in the entry mechanism for transport of Ca2+ through the sarcoplasmic reticulum Ca2+-ATPase.An efficient procedure to dialyze volumes in the range of 10-200 microliters.Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model.Involvement of the cytoplasmic loop L6-7 in the entry mechanism for transport of Ca2+ through the sarcoplasmic reticulum Ca2+-ATPase.Overcoming the toxicity of membrane peptide expression in bacteria by upstream insertion of Asp-Pro sequence.X-ray diffraction reveals the intrinsic difference in the physical properties of membrane and soluble proteins.Monoterpene indole alkaloid azine derivatives as MDR reversal agents.The cytoplasmic loop located between transmembrane segments 6 and 7 controls activation by Ca2+ of sarcoplasmic reticulum Ca2+-ATPase.Gradient reconstitution of membrane proteins for solid-state NMR studies.Modulators of the Efflux Pump Cdr1p of Candida albicans: Mechanisms of Action and Chemical Features.
P50
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P50
description
researcher ORCID ID = 0000-0002-9760-4577
@en
wetenschapper
@nl
name
Pierre Falson
@ast
Pierre Falson
@en
Pierre Falson
@es
Pierre Falson
@nl
type
label
Pierre Falson
@ast
Pierre Falson
@en
Pierre Falson
@es
Pierre Falson
@nl
prefLabel
Pierre Falson
@ast
Pierre Falson
@en
Pierre Falson
@es
Pierre Falson
@nl
P106
P31
P496
0000-0002-9760-4577