Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2

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Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2

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http://www.wikidata.org/entity/Q57974007

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im Juni 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в червні 2018

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Identification of a novel smal ...... se reaction catalysed by SIRT2

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Identification of a novel smal ...... se reaction catalysed by SIRT2

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Identification of a novel smal ...... se reaction catalysed by SIRT2

@en

Identification of a novel smal ...... se reaction catalysed by SIRT2

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Identification of a novel smal ...... se reaction catalysed by SIRT2

@en

Identification of a novel smal ...... se reaction catalysed by SIRT2

@nl

P1476

Identification of a novel smal ...... se reaction catalysed by SIRT2

@en

P2093

Akihiro Ito

http://www.w3.org/2001/XMLSchema#string

Akiko Nakata

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Mayumi Arata

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P2860

Structure of the histone deacetylase SIRT2

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

Crystal structures of human SIRT3 displaying substrate-induced conformational changes

MolProbity: all-atom structure validation for macromolecular crystallography

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

P304

20170070

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P31

scholarly article

P356

10.1098/RSTB.2017.0070

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P407

English

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1748

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P478

373

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P50

Minoru Yoshida

Norio Kudo

P577

2018-06-05T00:00:00Z

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P698

29685974

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P932

5915714

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