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Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp proteinAGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucusSpontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitisBlood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infectionThe inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaBicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection.Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation.An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants.The gastrointestinal mucus system in health and diseaseMucus and the goblet cell.Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli.The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.The composition of the gut microbiota shapes the colon mucus barrier.The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2.New developments in goblet cell mucus secretion and functionPerspectives on mucus properties and formation--lessons from the biochemical worldHelicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa.Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitisStudies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteinsAltered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon mucus.The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells.An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin.Is the intestinal goblet cell a major immune cell?Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice.Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression.Study of mucin turnover in the small intestine by in vivo labeling.Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic ActivityAnalysis of Assembly of Secreted MucinsPreservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISHKeeping Bacteria at a DistanceNovel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient miceThe Glycosylation of Rat Intestinal Muc2 Mucin Varies between Rat Strains and the Small and Large IntestineThe central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals
P50
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P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0002-4237-6677
@en
name
Malin E. V. Johansson
@ast
Malin E. V. Johansson
@en
Malin E. V. Johansson
@es
Malin E. V. Johansson
@nl
type
label
Malin E. V. Johansson
@ast
Malin E. V. Johansson
@en
Malin E. V. Johansson
@es
Malin E. V. Johansson
@nl
prefLabel
Malin E. V. Johansson
@ast
Malin E. V. Johansson
@en
Malin E. V. Johansson
@es
Malin E. V. Johansson
@nl
P106
P1153
25622190900
P31
P496
0000-0002-4237-6677