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Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendonsA hexadecylamide derivative of hyaluronan (HYMOVIS®) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronanOn the predictive utility of animal models of osteoarthritisBioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS).A commentary on modelling osteoarthritis pain in small animalsMatrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.Catabolism of aggrecan, decorin and biglycan in tendon.Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance.Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.A detailed microscopic examination of alterations in normal anular structure induced by mechanical destabilization in an ovine model of disc degeneration.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.S100A8 and S100A9 in experimental osteoarthritis.Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease.ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N-acetyl glucosamine, and sodium hyaluronan.Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep.Maintaining mRNA integrity during decalcification of mineralized tissues.Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairAre animal models useful for studying human disc disorders/degeneration?Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissuesPerlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.Drug insight: aggrecanases as therapeutic targets for osteoarthritis.Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.Histopathology atlas of animal model systems - overview of guiding principles.Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model.Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis.Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely".Mutations in TRPV4 cause an inherited arthropathy of hands and feet.Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy.Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development.Mesenchymal Stem Cell Treatment of Intervertebral Disc Lesion Prevents Fatty Infiltration and Fibrosis of the Multifidus Muscle, but not Cytokine and Muscle Fiber Changes.Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury.Tetanus in the horse: a review of 20 cases (1970 to 1990).Immunolocalization and distribution of proteoglycans in carious dentine.
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P50
description
researcher, ORCID id # 0000-0002-0353-7634
@en
wetenschapper
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name
Christopher B Little
@ast
Christopher B Little
@en
Christopher B Little
@es
Christopher B Little
@nl
type
label
Christopher B Little
@ast
Christopher B Little
@en
Christopher B Little
@es
Christopher B Little
@nl
prefLabel
Christopher B Little
@ast
Christopher B Little
@en
Christopher B Little
@es
Christopher B Little
@nl
P106
P1153
7202893520
P21
P31
P496
0000-0002-0353-7634