Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

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From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

P2860

Q58539497-C953AB59-6B8F-453A-8145-7C1AB7DCC25E

P2860

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

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http://www.wikidata.org/entity/Q58196866

description

article

@en

im März 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в березні 2018

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name

Structure-guided approach iden ...... e-directed mutagenesis studies

@en

Structure-guided approach iden ...... e-directed mutagenesis studies

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type

Item

label

Structure-guided approach iden ...... e-directed mutagenesis studies

@en

Structure-guided approach iden ...... e-directed mutagenesis studies

@nl

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Structure-guided approach iden ...... e-directed mutagenesis studies

@en

Structure-guided approach iden ...... e-directed mutagenesis studies

@nl

P1476

Structure-guided approach iden ...... e-directed mutagenesis studies

@en

P2093

Fabiana Pandolfi

http://www.w3.org/2001/XMLSchema#string

Roberta Costi

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P2860

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

Identification of a chemical probe for NAADP by virtual screening

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase

P304

562-575

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P31

scholarly article

P356

10.1039/C7MD00600D

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Vasanthanathan Poongavanam

P577

2018-02-01T00:00:00Z

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P698

30108947

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P921

Béésh Łikoní

P932

6072344

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Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

about

P2860

P2860

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932