Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

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Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

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im Januar 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 11 October 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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name

Teriflunomide Is an Indirect H ...... Growth Factor (EGF) Signaling

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Teriflunomide Is an Indirect Human Constitutive Androstane Receptor

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Item

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Teriflunomide Is an Indirect H ...... Growth Factor (EGF) Signaling

@en

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor

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Teriflunomide Is an Indirect H ...... Growth Factor (EGF) Signaling

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Teriflunomide Is an Indirect Human Constitutive Androstane Receptor

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P1476

Teriflunomide Is an Indirect H ...... Growth Factor (EGF) Signaling

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Alejandro Carazo

http://www.w3.org/2001/XMLSchema#string

Jan Dusek

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Josef Skoda

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Lucie Hyrsova

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Martin Dosedel

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Petr Pávek

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Tomas Smutny

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Tomas Soukup

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P2860

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.

A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene.

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

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993

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scholarly article

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10.3389/FPHAR.2018.00993

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English

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Ondrej Holas

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2018-10-11T00:00:00Z

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30364229

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Farmakologi

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6193428

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