Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

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The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease

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Q58577817-BF9D4311-0674-4EB5-8707-27979CA88391

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Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Immunotherapy targeting toll-l ...... smission and neuroinflammation

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Anthony Adame

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Brian Spencer

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Changyoun Kim

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Deborah Masliah

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Eliezer Masliah

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He-Jin Lee

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Hodaka Yamakado

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Jerel Adam Fields

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Michael Mante

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Michiyo Iba

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Glia and alpha-synuclein in neurodegeneration: A complex interaction

A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice

Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.

Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells.

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s13024-018-0276-2

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scholarly article

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10.1186/S13024-018-0276-2

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English

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Edward Rockenstein

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2018-08-09T00:00:00Z

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1106081807

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30092810

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6085656

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Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

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P2860

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

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P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P6179

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P6179

P698

P921

P932