about
Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analoguesEffects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water.The synthesis of gemcitabine.A linear synthesis of gemcitabine.Influence of Fluorination on the Conformational Properties and Hydrogen-Bond Acidity of Benzyl Alcohol Derivatives.Dietary Phytosterols Protective Against Peptic UlcerationA Study of Intramolecular Hydrogen Bonding in Levoglucosan Derivatives.Divergent synthetic approach to 6''-modified α-GalCer analogues.Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method.Intramolecular OH⋅⋅⋅Fluorine Hydrogen Bonding in Saturated, Acyclic Fluorohydrins: The γ-Fluoropropanol Motif.Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation.Synthesis and evaluation of amino-modified alpha-GalCer analogues.Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane.A novel, versatile D-->BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone.An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols.A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N'-diisopropylcarbodiimide.Efficient desymmetrization of "pseudo"-C2-symmetric substrates: illustration in the synthesis of a disubstituted butenolide from arabitol.Short synthesis of enantiopure C2-symmetric 1,2:4,5-diepoxypentane and "pseudo"-C2-symmetric 3-azido-1,2:4,5-diepoxypentane from arabitol.A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols.Design of fluorinated 5-HT(4)R antagonists: influence of the basicity and lipophilicity toward the 5-HT(4)R binding affinities.Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D.Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors.Influence of Alcohol β-Fluorination on Hydrogen-Bond Acidity of Conformationally Flexible Substrates.α-Fluoro-o-cresols: The Key Role of Intramolecular Hydrogen Bonding in Conformational Preference and Hydrogen-Bond Acidity.Synthesis and in vitro evaluation of alpha-GalCer epimers.6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice.Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside.Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity: application to UDP-Galp mutase inhibition.The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.Minimising conformational bias in fluoroprolines through vicinal difluorination.The development of a short route to the API ropinirole hydrochloride.Plant cell wall imaging by metabolic click-mediated labelling of rhamnogalacturonan II using azido 3-deoxy-D-manno-oct-2-ulosonic acid.Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidaseTransmembrane Exchange of Fluorosugars: Characterization of Red Cell GLUT1 Kinetics Using F NMRReducing the lipophilicity of perfluoroalkyl groups by CF2-F/CF2-Me or CF3/CH3 exchangeStereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated SulfinyliminesEnantioselective Synthesis of Dideoxy-tetrafluorinated HexosesThe conformation of tetrafluorinated methyl galactoside anomers: crystallographic and NMR studiesConformational influence of fluorinated building blocks on the physical properties of polyesters
P50
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P50
description
researcher ORCID ID = 0000-0001-8762-0170
@en
wetenschapper
@nl
name
Bruno Linclau
@ast
Bruno Linclau
@en
Bruno Linclau
@es
Bruno Linclau
@nl
type
label
Bruno Linclau
@ast
Bruno Linclau
@en
Bruno Linclau
@es
Bruno Linclau
@nl
prefLabel
Bruno Linclau
@ast
Bruno Linclau
@en
Bruno Linclau
@es
Bruno Linclau
@nl
P21
P31
P496
0000-0001-8762-0170