about
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neuronsSubset specification of central serotonergic neuronsEpigenetic mechanisms in the development and maintenance of dopaminergic neuronsModulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalitiesFoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttlingPhenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement componentsLmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2LMX1B is part of a transcriptional complex with PSPC1 and PSF.Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling.Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in miceEmbryonic development of selectively vulnerable neurons in Parkinson's disease.Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model.Phox2b influences the development of a caudal dopaminergic subset.Molecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons.Strategies to unravel molecular codes essential for the development of meso-diencephalic dopaminergic neurons.Molecular programming of stem cells into mesodiencephalic dopaminergic neurons.S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration.The serotonin 5-HT3 receptor: a novel neurodevelopmental target.FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development.Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset.Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives.A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b.Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function.Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets.Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic developmentMicrophthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.FoxK2 is required for cellular proliferation and survival.Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription.Tcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons.The BCL2 code to dopaminergic development and Parkinson's disease.Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice.Expression analyzes of early factors in midbrain differentiation programs.Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency.Pitx3 deficiency in mice affects cholinergic modulation of GABAergic synapses in the nucleus accumbens.Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1.
P50
Q24602724-DE000B76-7717-4784-9B3E-91328DFEC2D4Q26827511-FD05DF1F-E3A8-4BAE-BDBA-6E109A714996Q26866108-95A6FB46-5570-4CC8-853A-F03BF05453E9Q27300825-487BCD3D-71CE-4796-80AB-39B040E1B3C4Q28258996-A91257AC-8EF9-42A9-92AA-119056FABD56Q28506161-A9D4A268-0F33-4AA2-A189-D9CACDE80EDAQ28592910-2401AFA9-C198-4E37-9C88-17AAEA79C6D1Q30665216-6070EAA7-64F5-4EA3-8275-B3BE1949F13BQ33670401-1287FDE0-DD80-46FC-8298-DFFC7DEBD189Q33670401-7D6ECF12-9FC6-4984-A82A-66E29B0E9FFDQ33829295-2612758D-EDA2-4039-B7CA-123C5B5E634EQ33835242-E56B6EE6-EA0D-4984-8301-4AFFE657E0F9Q34369590-DD07880E-AADF-4D5D-B22E-EBA96D21A4DAQ34517627-190F000C-0EDD-40B1-8503-92CA51E9677BQ35014585-13DD9E22-59A0-48EB-B0B3-C15482DE6AA6Q36523582-26CB53B3-5085-4E24-B05F-7C847EC4F450Q36618717-9B4B296B-65AB-44BC-8365-3A449418E7CDQ36637329-F98DB735-D733-46B2-A65E-A1754E60E14AQ36894177-99DA7C94-C942-4AAE-9878-FC4C597C0FD5Q37417813-D12495B9-49FB-4D83-90FB-BDA403660427Q37583989-E33601F0-AA01-4193-B848-0952E11509EFQ38234170-021C5AE3-214F-4EB9-9DDB-4DF5800E9649Q38314171-61A556AD-9EB2-417F-92D6-9B55DCF9FCA0Q38752574-12CA53DC-D1DE-4308-B6E4-9AC13B6E77B1Q39252372-7880F699-09AE-4588-9E70-3802A38307E0Q39605796-511670AC-0612-4FC2-A30D-E01066F46B5EQ41050801-ACFA7C1B-A5BD-4124-A449-B5A84698CC33Q41363585-B5AE7B76-53B2-4149-83A6-BA67093684E9Q42356632-294829A9-9C55-4962-A14E-CAA5FAE44F0BQ42644001-46737861-BDB5-4F26-A973-24CF288B38E3Q42795738-A6F3A230-6D22-48F4-82D4-2CE46B173AFBQ43564367-17BA4BF1-6CFE-4211-AEF0-333E3BE3FE15Q44336809-46F0EEAA-2C08-4ED8-8BAF-61F4452B252CQ46020868-D8FFF3B7-30C0-4E17-9ED7-7AAB5687AC7EQ46430873-B3237FFF-8F49-4B50-A874-749966DD7776Q46444138-E1221273-9FC6-41AF-A61F-1871554DB215Q46794636-690F073D-2183-4C3E-849A-25DD70789168Q47294006-7F63617F-82FC-473A-84FE-D517A2D4FE22Q48126278-261FE97B-6B0D-4D94-9571-CF5A27B0E06CQ48473411-31CD44C2-AF73-43C9-BA2E-7BF72FFCF891
P50
description
researcher ORCID ID = 0000-0002-8815-747X
@en
wetenschapper
@nl
name
Marten P Smidt
@ast
Marten P Smidt
@en
Marten P Smidt
@nl
type
label
Marten P Smidt
@ast
Marten P Smidt
@en
Marten P Smidt
@nl
altLabel
Marten Smidt
@en
Marten Smidt
@nl
prefLabel
Marten P Smidt
@ast
Marten P Smidt
@en
Marten P Smidt
@nl
P106
P21
P31
P496
0000-0002-8815-747X