about
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideStructure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogsA novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligaseIdentification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol AHigh-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads.Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).Deciphering the mystery of thalidomide teratogenicity.Discovery of the target for immunomodulatory drugs (IMiDs).Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain.Myeloid disease: Another action of a thalidomide derivative.GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesisTools and methodologies capable of isolating and identifying a target molecule for a bioactive compoundGenome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomideCereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
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description
researcher ORCID ID = 0000-0002-9997-2664
@en
wetenschapper
@nl
name
Takumi Ito
@ast
Takumi Ito
@en
Takumi Ito
@es
Takumi Ito
@nl
type
label
Takumi Ito
@ast
Takumi Ito
@en
Takumi Ito
@es
Takumi Ito
@nl
prefLabel
Takumi Ito
@ast
Takumi Ito
@en
Takumi Ito
@es
Takumi Ito
@nl
P106
P1153
55249619900
P31
P496
0000-0002-9997-2664