about
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transductionTRIL, a functional component of the TLR4 signaling complex, highly expressed in brainA Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosisActivation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.TRIL is involved in cytokine production in the brain following Escherichia coli infection.Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors.ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance.NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.Adaptor usage and Toll-like receptor signaling specificity.DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative diseaseNew insights into the post-translational modification of Toll-like receptor signaling molecules.TLR based therapeutics.Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transductionSuppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation.Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.Investigating inflammasome activation under conditions of cellular stress and injury.A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.Activation of human biliverdin-IXα reductase by urea: generation of kinetically distinct forms during the unfolding pathway.Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase.Growth plate extracellular matrix-derived scaffolds for large bone defect healing.Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner.Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling.Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells.Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.Calcium crystal deposition diseases - beyond goutTissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissuesImmune modulation: IL-1, master mediator or initiator of inflammationPlant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment.The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defenseTrypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and MacrophagesChronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progressionCalcium crystals and auto-inflammation
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description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-2342-9518
@en
name
Aisling Dunne
@ast
Aisling Dunne
@en
Aisling Dunne
@es
Aisling Dunne
@nl
type
label
Aisling Dunne
@ast
Aisling Dunne
@en
Aisling Dunne
@es
Aisling Dunne
@nl
prefLabel
Aisling Dunne
@ast
Aisling Dunne
@en
Aisling Dunne
@es
Aisling Dunne
@nl
P106
P31
P496
0000-0002-2342-9518