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Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranesEffects of iodination of tyrosyl residues on the binding and action of glucagon at its receptorHydroxybenzylpindolol and hydroxybenzylpropranolol: partial beta adrenergic agonists of adenylate cyclase in the rat adipocyteGlucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclaseMicrosomal and cytosolic fractions of guinea pig hepatocytes contain 100-kilodalton GTP-binding proteins reactive with antisera against alpha subunits of stimulatory and inhibitory heterotrimeric GTP-binding proteins.Octyl glucoside extracts GTP-binding regulatory proteins from rat brain "synaptoneurosomes" as large, polydisperse structures devoid of beta gamma complexes and sensitive to disaggregation by guanine nucleotides.Pertussis toxin induces structural changes in G alpha proteins independently of ADP-ribosylation.The role of hormone receptors and GTP-regulatory proteins in membrane transduction.Signal transduction: evolution of an idea.The beginnings of an endocrinologist.Simple model for hormone-activated adenylate cyclase systemsThe role of GTP-binding proteins in signal transduction: from the sublimely simple to the conceptually complex.Structure of the turkey erythrocyte adenylate cyclase system.The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated.Heterotrimeric G proteins in synaptoneurosome membranes are crosslinked by p-phenylenedimaleimide, yielding structures comparable in size to crosslinked tubulin and F-actin.5'-Guanylylimidodiphosphate, a potent activator of adenylate cyclase systems in eukaryotic cells.The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule.Carbachol-activated muscarinic (M1 and M3) receptors transfected into Chinese hamster ovary cells inhibit trafficking of endosomesAdenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.Isoproterenol stimulates shift of G proteins from plasma membrane to pinocytotic vesicles in rat adipocytes: a possible means of signal disseminationRole of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multisite transition states.Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes.The actions of insulin and catabolic hormones on the plasma membrane of the fat cells.The fat cell in mid-term: its past and future.The role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multi-site transition states.A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes.Multiple inhibitory and activating effects of nucleotides and magnesium on adrenal adenylate cyclase.Structure-function relationships in glucagon: properties of highly purified des-His-1-, monoiodo-, and (des-Asn-28, Thr-29)(homoserine lactone-27)-glucagon.Semisynthetic glucagon derivatives for structure-function studies.Evidence for distinct guanine nucleotide sites in the regulation of the glucagon receptor and of adenylate cyclase activity.Solubilization and separation of the glucagon receptor and adenylate cyclase in guanine nucleotide-sensitive states.Structure-function problems with the adenylate cyclase system.A reassessment of structure-function relationships in glucagon. Glucagon1-21 is a full agonist.The actions of hormones on adenylate cyclase systems.Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH.On the mechanism of activation of fat cell adenylate cyclase by guanine nucleotides. An explanation for the biphasic inhibitory and stimulatory effects of the nucleotides and the role of hormones.Nobel Lecture. Signal transduction: evolution of an idea.Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an "excited" state of GTPase is a control component of the system.
P50
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P50
description
American biochemist
@en
Amerikaans biochemicus (1925-1998)
@nl
Amerikalı biyokimyacı
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US-amerikanischer Biochemiker
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biochimico statunitense
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biocimiciste american
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bioquímico estadounidense (1925-1998)
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bithchemiceoir Meiriceánach
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chimiste américain
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usona biokemiisto
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name
Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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type
label
Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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altLabel
M Rodbell
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M. Rodbell
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Rodbell M
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Rodbell M.
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Rodbell
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Rodbell
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Rodbell
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Мартин Родбелл
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Родбелл Мартин
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Родбелл
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prefLabel
Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
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Martin Rodbell
@de
Martin Rodbell
@en
Martin Rodbell
@es
Martin Rodbell
@fi
Martin Rodbell
@fr