about
Gonadal steroids differentially modulate the actions of orphanin FQ/nociceptin at a physiologically relevant circuit controlling female sexual receptivity.Estradiol negatively modulates the pleiotropic actions of orphanin FQ/nociceptin at proopiomelanocortin synapses.Estrogen and endogenous opioids regulate CCK in reproductive circuits.17β-estradiol rapidly facilitates lordosis through G protein-coupled estrogen receptor 1 (GPER) via deactivation of medial preoptic nucleus μ-opioid receptors in estradiol primed female rats.Estradiol upregulates progesterone receptor and orphanin FQ colocalization in arcuate nucleus neurons and opioid receptor-like receptor-1 expression in proopiomelanocortin neurons that project to the medial preoptic nucleus in the female rat.Oestrogen modulates cholecystokinin: opioid interactions in the nervous system.Visualizing activation of opioid circuits by internalization of G protein-coupled receptors.Orphanin FQ in the mediobasal hypothalamus facilitates sexual receptivity through the deactivation of medial preoptic nucleus mu-opioid receptors.Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosisThe Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH SurgeEstradiol signaling in the regulation of reproduction and energy balanceSynthesis and function of hypothalamic neuroprogesterone in reproduction.Neuroprogesterone: key to estrogen positive feedback?Estradiol dose-dependent regulation of membrane estrogen receptor-α, metabotropic glutamate receptor-1a, and their complexes in the arcuate nucleus of the hypothalamus in female rats.Actions of Steroids: New Neurotransmitters.Temporal and concentration-dependent effects of oestradiol on neural pathways mediating sexual receptivity.Orphanin FQ-ORL-1 regulation of reproduction and reproductive behavior in the female.Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization.Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.Medial preoptic area delta-opioid receptors inhibit lordosis.Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse.The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats.NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice.Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures.Preproenkephalin mRNA levels are regulated by acute stress and estrogen stimulation.Extranuclear signaling by ovarian steroids in the regulation of sexual receptivityPlasma membrane G protein-coupled estrogen receptor 1 (GPER) mediates rapid estradiol facilitation of sexual receptivity through the orphanin-FQ-ORL-1 system in estradiol primed female rats
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description
researcher ORCID ID = 0000-0001-8843-4708
@en
wetenschapper
@nl
name
Kevin Sinchak
@ast
Kevin Sinchak
@en
Kevin Sinchak
@es
Kevin Sinchak
@nl
type
label
Kevin Sinchak
@ast
Kevin Sinchak
@en
Kevin Sinchak
@es
Kevin Sinchak
@nl
prefLabel
Kevin Sinchak
@ast
Kevin Sinchak
@en
Kevin Sinchak
@es
Kevin Sinchak
@nl
P1153
8732885000
P31
P496
0000-0001-8843-4708