about
Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyActivation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/GirdinAMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.Mitochondrial BMI1 maintains bioenergetic homeostasis in cells.A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development.Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous MelanomaIncreased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity.Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors
P50
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P50
description
researcher ORCID ID = 0000-0003-3338-9932
@en
name
Nicolas Aznar
@ast
Nicolas Aznar
@en
Nicolas Aznar
@es
Nicolas Aznar
@nl
type
label
Nicolas Aznar
@ast
Nicolas Aznar
@en
Nicolas Aznar
@es
Nicolas Aznar
@nl
prefLabel
Nicolas Aznar
@ast
Nicolas Aznar
@en
Nicolas Aznar
@es
Nicolas Aznar
@nl
P21
P31
P496
0000-0003-3338-9932