about
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growthTranscription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1Palm is expressed in both developing and adult mouse lens and retina.Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in vivoStructure of the retinal determination protein Dachshund reveals a DNA binding motifFunctional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferationCited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesisCell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotypeCell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growthMammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeatIdentification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiationChromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleationIdentification of differentially expressed genes in mouse Pax6 heterozygous lenses.Rybp, a polycomb complex-associated protein, is required for mouse eye development.Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivatesIdentification of pax6-dependent gene regulatory networks in the mouse lens.Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions.Cataract- and lens-specific upregulation of ARK receptor tyrosine kinase in Emory mouse cataract.Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrainPax6 regulates gene expression in the vertebrate lens through miR-204The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseasesRegulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells.Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.Tissue-specific regulation of the mouse alphaA-crystallin gene in lens via recruitment of Pax6 and c-Maf to its promoter.Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insultFunctional properties of natural human PAX6 and PAX6(5a) mutantsGenetic and epigenetic mechanisms of gene regulation during lens development.Large Maf Transcription Factors: Cousins of AP-1 Proteins and Important Regulators of Cellular Differentiation.Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataractRegulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers.Retinoic acid signaling in mammalian eye development.Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays.
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onderzoeker
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հետազոտող
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Ales Cvekl
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Ales Cvekl
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Ales Cvekl
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P31
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0000-0002-3957-789X