about
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complexTwo subunits of human ORC are dispensable for DNA replication and proliferation.CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradationDegradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathwayThe MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationHuman Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.
P50
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P50
name
Etsuko Shibata
@ast
Etsuko Shibata
@en
Etsuko Shibata
@es
Etsuko Shibata
@nl
type
label
Etsuko Shibata
@ast
Etsuko Shibata
@en
Etsuko Shibata
@es
Etsuko Shibata
@nl
prefLabel
Etsuko Shibata
@ast
Etsuko Shibata
@en
Etsuko Shibata
@es
Etsuko Shibata
@nl