about
Hearing loss is an early consequence of Npc1 gene deletion in the mouse model of Niemann-Pick disease, type C.Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function.Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient miceReversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse.Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream.Carboxylesterases are uniquely expressed among tissues and regulated by nuclear hormone receptors in the mouse.Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy.Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons.Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Anna M Taylor
@ast
Anna M Taylor
@en
Anna M Taylor
@es
Anna M Taylor
@nl
type
label
Anna M Taylor
@ast
Anna M Taylor
@en
Anna M Taylor
@es
Anna M Taylor
@nl
prefLabel
Anna M Taylor
@ast
Anna M Taylor
@en
Anna M Taylor
@es
Anna M Taylor
@nl
P106
P1153
55473424000
57199266625
P31
P496
0000-0002-1991-078X