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Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3Rotavirus diversity and evolution in the post-vaccine worldRotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7The battle between rotavirus and its host for control of the interferon signaling pathwayCrystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like ActivityRotavirus protein involved in genome replication and packaging exhibits a HIT-like foldCrystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase ActivityFeatures of the 3'-consensus sequence of rotavirus mRNAs critical to minus strand synthesisThe rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymeraseCritical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNAComparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 ComplexEvolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations.Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment.Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.Mechanism of intraparticle synthesis of the rotavirus double-stranded RNA genome.Predicted structure and domain organization of rotavirus capping enzyme and innate immune antagonist VP3Absence of genetic differences among G10P[11] rotaviruses associated with asymptomatic and symptomatic neonatal infections in Vellore, India.Analysis of human rotaviruses from a single location over an 18-year time span suggests that protein coadaption influences gene constellations.Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116ERotavirus glycoprotein NSP4 is a modulator of viral transcription in the infected cell.Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirusStructure and function of the rotavirus RNA-binding proteins.Nonstructural proteins involved in genome packaging and replication of rotaviruses and other members of the Reoviridae.RNA-binding activity of the rotavirus phosphoprotein NSP5 includes affinity for double-stranded RNA.Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.De novo synthesis of minus strand RNA by the rotavirus RNA polymerase in a cell-free system involves a novel mechanism of initiation.A base-specific recognition signal in the 5' consensus sequence of rotavirus plus-strand RNAs promotes replication of the double-stranded RNA genome segmentsRegulation of rotavirus polymerase activity by inner capsid proteins.Residues of the rotavirus RNA-dependent RNA polymerase template entry tunnel that mediate RNA recognition and genome replicationDiversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains.Rotavirus VP2 core shell regions critical for viral polymerase activation.Assortment and packaging of the segmented rotavirus genome.Structure-function analysis of rotavirus NSP2 octamer by using a novel complementation system.Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.Rotavirus antagonism of the innate immune responsePrimed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry IntermediateStructural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq.Rotavirus Infects Human Biliary Epithelial Cells and Stimulates Secretion of Cytokines IL-6 and IL-8 via MAPK Pathway.Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities
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Forscher
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John T Patton
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John T Patton
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John T Patton
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John T Patton
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John T Patton
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John T Patton
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John T Patton
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John T Patton
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P31
P496
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