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Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular SystemCellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH releaseDehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neuronsPhysiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanineAngiotensin III: a central regulator of vasopressin release and blood pressure.Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertensionOrganisation and functional role of the brain angiotensin system.Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuliAminopeptidase A inhibitors as centrally acting antihypertensive agents.The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions.The role of the brain renin-angiotensin system in hypertension: implications for new treatment.Apelin in the control of body fluid homeostasis and cardiovascular functions.A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors.Study of asparagine 353 in aminopeptidase A: characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases.A glutamate residue contributes to the exopeptidase specificity in aminopeptidase ADirected Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities.Plasma Apelin Concentrations in Patients With Polyuria-Polydipsia Syndrome.Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a.Production and properties of a recombinant soluble form of aminopeptidase A.Regulation of somatostatin synthesis by GABAA receptor stimulation in mouse brain.Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review.Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residuesBy interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.A tyrosine residue essential for catalytic activity in aminopeptidase A.[Contribution of apelin to water balance, blood glucose control, and cardiovascular functions].Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry.Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons.The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase.Synthesis and in vitro activities of new non-peptidic APA inhibitors.Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.Roles of brain angiotensins II and III in thirst and sodium appetite.Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems.Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats.
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