about
Phenotypes on demand via switchable target protein degradation in multicellular organisms.Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMOUmp1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizymeProteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomesPolyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA.Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathwayHsm3/S5b joins the ranks of 26S proteasome assembly chaperonesN-recognin/Ubc2 interactions in the N-end rule pathway.The ultimate nanoscale mincer: assembly, structure and active sites of the 20S proteasome core.Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.SUMO protein modification.PACemakers of proteasome core particle assembly.Catalytic mechanism and assembly of the proteasome.SUMO-targeted ubiquitin ligases.Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells.Arsenic trioxide stimulates SUMO-2/3 modification leading to RNF4-dependent proteolytic targeting of PML.Assays for proteasome assembly and maturation.In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.SUMO wrestles down myc.Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome.Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control.A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast.Role of C-terminal extensions of subunits beta2 and beta7 in assembly and activity of eukaryotic proteasomes.Heat-inducible degron: a method for constructing temperature-sensitive mutants.In Vitro Characterization of Chain Depolymerization Activities of SUMO-Specific Proteases.Varshavsky's contributions.Analysis of Cotranslational Polyamine Sensing During Decoding of ODC Antizyme mRNA.Regulated overproduction of alpha-amylase by transformation of the amylolytic yeast Schwanniomyces occidentalisCharacterization of the active site of Schwanniomyces occidentalis glucoamylase by in vitro mutagenesisSUMO conjugation and deconjugationInducible degron and its application to creating conditional mutantsSumoylation as a signal for polyubiquitylation and proteasomal degradationAnalysis of cellular SUMO and SUMO-ubiquitin hybrid conjugatesProteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperoneDual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylationMethods to study SUMO dynamics in yeastArkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
P50
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P50
description
researcher
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wetenschapper
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name
R J Dohmen
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R J Dohmen
@en
R J Dohmen
@nl
type
label
R J Dohmen
@ast
R J Dohmen
@en
R J Dohmen
@nl
prefLabel
R J Dohmen
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R J Dohmen
@en
R J Dohmen
@nl
P106
P31
P496
0000-0002-5756-6780