about
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteresQuinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activityStructure-Guided Rescaffolding of Selective Antagonists of BCL-X LAlbumin affinity tags increase peptide half-life in vivo.The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues.Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.Structural basis for dual-mode inhibition of the ABC transporter MsbAOptimized arylomycins are a new class of Gram-negative antibioticsPhosphate ester serum albumin affinity tags greatly improve peptide half-life in vivoA new synthetic approach to the C ring of known as well as novel bryostatin analogues
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description
researcher
@en
wetenschapper
@nl
name
Koehler MF
@nl
Michael F. Koehler
@en
type
label
Koehler MF
@nl
Michael F. Koehler
@en
altLabel
Koehler MF
@en
prefLabel
Koehler MF
@nl
Michael F. Koehler
@en
P106
P31
P496
0000-0003-0967-8304