about
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsSalicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanismVascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signalingTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationThe RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptorExpression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cellsCellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor proteinPirin inhibits cellular senescence in melanocytic cells.Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.RNAi screens identify CHD4 as an essential gene in breast cancer growth.Molecular networks in melanoma invasion and metastasis.Interrogating open issues in cancer precision medicine with patient-derived xenografts.In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.Investigating the metastatic niche in melanoma: a new therapeutic opportunity?Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.Melanoma: targeting signaling pathways and RaLPp53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic ValueThe chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 breast cancer cellsc-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cellsRetroviral gene transfer, rapid selection, and maintenance of the immature phenotype in mouse dendritic cellsp52Shc is required for CXCR4-dependent signaling and chemotaxis in T cellsWDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cellsModeling cell proliferation in human acute myeloid leukemia xenograftsCombination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 AxisDevelopment of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs
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P50
description
researcher
@en
name
L Lanfrancone
@en
L Lanfrancone
@nl
type
label
L Lanfrancone
@en
L Lanfrancone
@nl
prefLabel
L Lanfrancone
@en
L Lanfrancone
@nl
P106
P31
P496
0000-0002-4523-3815