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Combined Effects of Lipophilic Phycotoxins (Okadaic Acid, Azapsiracid-1 and Yessotoxin) on Human Intestinal Cells ModelsA strategy to study genotoxicity: application to aquatic toxins, limits and solutions.Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells.Comparative analysis of the cytotoxic effects of okadaic acid-group toxins on human intestinal cell lines.Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo genotoxicity.In vitro combined cytotoxic effects of pesticide cocktails simultaneously found in the French diet.Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays.Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells.Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.Marine toxin okadaic acid induces aneuploidy in CHO-K1 cells in presence of rat liver postmitochondrial fraction, revealed by cytokinesis-block micronucleus assay coupled to FISH.Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts.Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells.A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes.Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment.Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines.Cytotoxic and genotoxic effects of cylindrospermopsin in mice treated by gavage or intraperitoneal injectionGenotoxicity of Aluminum and Aluminum Oxide Nanomaterials in Rats Following Oral ExposureCombined effects of okadaic acid and pectenotoxin-2, 13-desmethylspirolide C or yessotoxin in human intestinal Caco-2 cellsThree-dimensional HepaRG spheroids as a liver model to study human genotoxicity in vitro with the single cell gel electrophoresis assay
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description
researcher
@en
wetenschapper
@nl
name
Ludovic Le Hegarat
@en
Ludovic Le Hegarat
@nl
type
label
Ludovic Le Hegarat
@en
Ludovic Le Hegarat
@nl
prefLabel
Ludovic Le Hegarat
@en
Ludovic Le Hegarat
@nl
P106
P31
P496
0000-0003-3494-4109