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Resistance of young rat hepatic mitochondria to bile acid-induced permeability transition: potential role of alpha-tocopherolIncreased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndromeVitamin E delivery to human skin: studies using deuterated alpha-tocopherol measured by APCI LC-MS.Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletionIncreased vitamin E intake is associated with higher alpha-tocopherol concentration in the maternal circulation but higher alpha-carboxyethyl hydroxychroman concentration in the fetal circulation.Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study.Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats.α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymesNovel function of vitamin E in regulation of zebrafish (Danio rerio) brain lysophospholipids discovered using lipidomics.Burn and smoke inhalation injury in sheep depletes vitamin E: kinetic studies using deuterated tocopherols.α-Tocopherol supplementation reduces 5-nitro-γ-tocopherol accumulation by decreasing γ-tocopherol in young adult smokersGamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome.ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol.Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects.Genome wide responses of murine lungs to dietary alpha-tocopherolVitamins C and E improve regrowth and reduce lipid peroxidation of blackberry shoot tips following cryopreservation.Alpha-tocopherol beta-oxidation localized to rat liver mitochondria.Regulatory mechanisms to control tissue alpha-tocopherol.Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery.Vitamin E and C supplementation does not ameliorate muscle dysfunction after anterior cruciate ligament surgery.Vitamin E supplementation increases circulating vitamin E metabolites tenfold in end-stage renal disease patients.5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo.Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice.Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets.Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration.Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production.Gene-nutrient interactions exemplified by the alpha-tocopherol content of tissues from alpha-tocopherol transfer protein-null mice fed different dietary vitamin E concentrations.Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.High-Dietary Alpha-Tocopherol or Mixed Tocotrienols Have No Effect on Bone Mass, Density, or Turnover in Male Rats During Skeletal Maturation.Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents.Vitamins E and C modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery.Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress.Vitamin E bioavailability from fortified breakfast cereal is greater than that from encapsulated supplements.Human vitamin E requirements assessed with the use of apples fortified with deuterium-labeled alpha-tocopheryl acetate.Conjugated Linoleic Acid and Fish Oil in Laying Hen Diets: Effects on Egg Fatty Acids, Thiobarbituric Acid Reactive Substances, and Tocopherols During StorageDietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanesResponse to Harri Hemilä, “Conclusions about intervention effects should not be based on surrogate end points”
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P50
description
researcher
@en
wetenschapper
@nl
name
Scott W Leonard
@en
Scott W Leonard
@nl
type
label
Scott W Leonard
@en
Scott W Leonard
@nl
prefLabel
Scott W Leonard
@en
Scott W Leonard
@nl
P106
P31
P496
0000-0001-9967-7078