about
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane divisionAssembling the puzzle: Oligomerization of α-pore forming proteins in membranesDynamic interaction of cBid with detergents, liposomes and mitochondria.Peptides in apoptosis research.New biophysical methods to study the membrane activity of Bcl-2 proteins.Scanning fluorescence correlation spectroscopy on biomembranes.Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric speciesMembranes in motion: mitochondrial dynamics and their role in apoptosis.Mitochondrial alterations in apoptosis.Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes.Apoptotic foci at mitochondria: in and around Bax pores.Automated analysis of giant unilamellar vesicles using circular Hough transformation.Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteinsFormation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.Differences in activity of actinoporins are related with the hydrophobicity of their N-terminus.Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.7th Tuscany Retreat on Cancer Research: genetic profiling, resistance mechanism and novel treatment concepts in cancer.Toxicity of an α-pore-forming toxin depends on the assembly mechanism on the target membrane as revealed by single molecule imaging.Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid BilayersProapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size.Giant unilamellar vesicles (GUVs) as a new tool for analysis of caspase-8/Bid-FL complex binding to cardiolipin and its functional activity.Structural model of active Bax at the membrane.A single herpesvirus protein can mediate vesicle formation in the nuclear envelopePore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.Cardiolipin effects on membrane structure and dynamics.Destabilization exerted by peptides derived from the membrane-proximal external region of HIV-1 gp41 in lipid vesicles supporting fluid phase coexistence.Membrane promotes tBID interaction with BCL(XL).Determinants of BH3 Sequence Specificity for the Disruption of Bcl-xL/cBid Complexes in Membranes.Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol.Drp1 polymerization stabilizes curved tubular membranes similar to those of constricted mitochondria.Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid poresMembrane-insertion fragments of Bcl-xL, Bax, and BidFluorescence correlation spectroscopy for the study of membrane dynamics and organization in giant unilamellar vesiclesA new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labelsDrp1 modulates mitochondrial stress responses to mitotic arrestMIM through MOM: the awakening of Bax and Bak pores
P50
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P50
description
Forscher
@de
investigador
@es
researcher
@en
ricercatore
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wetenschapper
@nl
研究員
@ja
研究者
@zh
name
Ana J García-Sáez
@en
Ana J García-Sáez
@nl
type
label
Ana J García-Sáez
@en
Ana J García-Sáez
@nl
prefLabel
Ana J García-Sáez
@en
Ana J García-Sáez
@nl
P106
P31
P496
0000-0002-3894-5945