about
Full-length HIV type 1 proviral sequencing of 10 highly exposed women from Nairobi, Kenya reveals a high proportion of intersubtype recombinants.HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers.Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition.Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection.Effect of baseline HIV disease parameters on CD4+ T cell recovery after antiretroviral therapy initiation in Kenyan women.Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix.Influence of HLA class I haplotypes on HIV-1 seroconversion and disease progression in Pumwani sex worker cohort.Molecular definition of vaginal microbiota in East African commercial sex workers.A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort.Microarray analysis of HIV resistant female sex workers reveal a gene expression signature pattern reminiscent of a lowered immune activation state.Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in KenyaReduced cellular susceptibility to in vitro HIV infection is associated with CD4+ T cell quiescence.CD26/dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected female sex workersEpitope mapping of HIV-specific CD8+ T cell responses by multiple immunological readouts reveals distinct specificities defined by function.Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.Enumeration of sex workers in the central business district of Nairobi, Kenya.For protection from HIV-1 infection, more might not be better: a systematic analysis of HIV Gag epitopes of two alleles associated with different outcomes of HIV-1 infection.The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation.Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cellsDoes antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case-control study"How I Wish This Thing Was Initiated 100 Years Ago!" Willingness to Take Daily Oral Pre-Exposure Prophylaxis among Men Who Have Sex with Men in KenyaSelection, phenotyping and identification of acid and hydrogen peroxide producing bacteria from vaginal samples of Canadian and East African women.A genetic polymorphism of FREM1 is associated with resistance against HIV infection in the Pumwani sex worker cohort.HIV-1 clade D is associated with increased rates of CD4 decline in a Kenyan cohort.An integrative bioinformatic approach for studying escape mutations in human immunodeficiency virus type 1 gag in the Pumwani Sex Worker Cohort.Human immunodeficiency virus (HIV) type 1 proviral hypermutation correlates with CD4 count in HIV-infected women from Kenya.Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility.A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24.Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract.HIV postexposure prophylaxis in an urban population of female sex workers in Nairobi, Kenya.High prevalence of genetically similar HIV-1 recombinants among infected sex workers in Nairobi, Kenya.CD4+ T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women.Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells.Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers.Associations of human leukocyte antigen-G with resistance and susceptibility to HIV-1 infection in the Pumwani sex worker cohort.Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection.HIV‐exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV‐dependent host factors.Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis.Bacterial vaginosis in HIV-infected women induces reversible alterations in the cervical immune environment.
P50
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P50
name
Charles Wachihi
@en
Charles Wachihi
@nl
type
label
Charles Wachihi
@en
Charles Wachihi
@nl
prefLabel
Charles Wachihi
@en
Charles Wachihi
@nl