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Is the oxidative stress theory of aging dead?Insulin resistance is a cellular antioxidant defense mechanismThe in vivo gene expression signature of oxidative stressOxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate agingTrends in oxidative aging theoriesDietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALSMnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse modelsp53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injuryAbsence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophyComplex III releases superoxide to both sides of the inner mitochondrial membraneMultiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stressElevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelinationThe selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insultsGlutathione-peroxidase-1 null muscle progenitor cells are globally defectiveMicrowave & Magnetic (M2) Proteomics of a Mouse Model of Mild Traumatic Brain Injury.Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging MiceA strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice.Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics.Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis.A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria.The effects of dietary restriction on oxidative stress in rodents.Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficienciesThe lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation.Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.Methionine oxidation and aging.High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates.Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery.Mitochondrial stress signaling in longevity: a new role for mitochondrial function in agingReduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging.Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degenerationCuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.Age-related loss of the DNA repair response following exposure to oxidative stress.Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis.MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during agingReduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose toleranceOxidative damage to DNA and aging.
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P50
name
Holly Van Remmen
@en
Holly Van Remmen
@nl
type
label
Holly Van Remmen
@en
Holly Van Remmen
@nl
prefLabel
Holly Van Remmen
@en
Holly Van Remmen
@nl