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Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfurationDisruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice.A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisNuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiencyVitamin B-6Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.Bringing clarity to the role of MTHFR variants in neural tube defect prevention.New insights into the metabolic and nutritional determinants of severe combined immunodeficiency.Dietary folic acid protects against genotoxicity in the red blood cells of mice.Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.Targeting nuclear thymidylate biosynthesis.Folate nutrition and blood-brain barrier dysfunction.Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma.Time to Think About Nutrient Needs in Chronic Disease.Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.Inhibition of 5,10-methenyltetrahydrofolate synthetase.Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability.Safety of folic acid.The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNAThe 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolismCell cycle regulation of folate-mediated one-carbon metabolismDietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal CancerUnexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesisNuclear Folate MetabolismBest practices in nutrition science to earn and keep the public's trustDeoxyuracil in DNA and disease: Genomic signal or managed situation?The Role of Brain Barriers in Maintaining Brain Vitamin Levels
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Martha S Field
@en
Martha S Field
@nl
type
label
Martha S Field
@en
Martha S Field
@nl
prefLabel
Martha S Field
@en
Martha S Field
@nl
P31
P496
0000-0001-7547-5180