about
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling.Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study.A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.Application of Free Energy Perturbation for the Design of BACE1 Inhibitors.Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation.Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization.The size matters? A computational tool to design bivalent ligandsComputational Drug Design Applied to the Study of Metabotropic Glutamate ReceptorsDeltaDelta neural networks for lead optimization of small molecule potencyComputationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 ReceptorPredicting Activity Cliffs with Free-Energy PerturbationMechanisms Underlying Allosteric Molecular Switches of Metabotropic Glutamate Receptor 5
P50
Q27305013-5E177FE7-B536-4C88-8DE3-5B22173698A5Q34539042-3B9A106C-4E53-4CBC-A3EF-C909F308D597Q35721866-B49CD27C-C3D0-4169-936C-8019D34F2E5FQ38666977-CF3B68A8-8DA5-4697-B0B0-693AE1191CD6Q42700069-AFB4B33A-8BBE-4208-B251-00540843BA30Q47172533-B5C3F920-2876-4C49-965F-BCC6DDD210E9Q48049367-756258A5-04FD-4C38-861F-A04322CB3FABQ50957567-6AC7D6BF-90BD-4B09-B6D2-52242927F881Q51586173-295933AF-F4F0-4224-9C38-0705B261EA09Q52372072-CF6F5AE8-C90F-4E16-B9F6-8A40CCC81F84Q52646070-981B2545-3FA6-4BE4-8D8A-49C6EFBFB995Q52679428-B0038FF0-CED9-4BCD-A5FD-C8CEEAAE20BEQ59287278-A8BE17EB-0596-4FBF-805C-E00A43368F36Q64071827-C158AE9F-5D8D-44FD-8B78-1AB9505665CEQ90448040-CB57C466-4364-4458-A2D7-F3B726AF25A5Q91447097-85194B53-114E-40B8-AF61-21353A9BBE4CQ91677132-15E8A6FB-8F45-4D17-A054-BBCD0A67B777Q91962640-E0F666C3-1FD6-482A-B525-D9F52D9C58D2
P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Laura Pérez-Benito
@en
Laura Pérez-Benito
@nl
type
label
Laura Pérez-Benito
@en
Laura Pérez-Benito
@nl
prefLabel
Laura Pérez-Benito
@en
Laura Pérez-Benito
@nl
P31
P496
0000-0001-9607-9048