about
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesmiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypesIdentification of ALK as a major familial neuroblastoma predisposition geneNo evidence for involvement of SDHD in neuroblastoma pathogenesisQuantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNACombined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA ampliconsPositional and functional mapping of a neuroblastoma differentiation gene on chromosome 11arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays.RTPrimerDB: the real-time PCR primer and probe database, major update 2006.CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients.Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.Focal DNA copy number changes in neuroblastoma target MYCN regulated genesDickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastomaClinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell linesA novel gene family NBPF: intricate structure generated by gene duplications during primate evolutionLoss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosisThe von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastomaA p53 drug response signature identifies prognostic genes in high-risk neuroblastomaPHF6 mutations in T-cell acute lymphoblastic leukemiaqBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR dataDNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing.RNA pre-amplification enables large-scale RT-qPCR gene-expression studies on limiting sample amountsA cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis typeApplication of laser capture microdissection in genetic analysis of neuroblastoma and neuroblastoma precursor cells.Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genesmethBLAST and methPrimerDB: web-tools for PCR based methylation analysis.A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genesCADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23EVI1 activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22).A novel and universal method for microRNA RT-qPCR data normalization.Disease-causing 7.4 kb cis-regulatory deletion disrupting conserved non-coding sequences and their interaction with the FOXL2 promotor: implications for mutation screening.External oligonucleotide standards enable cross laboratory comparison and exchange of real-time quantitative PCR data.Array comparative genomic hybridization and flow cytometry analysis of spontaneous abortions and mors in utero samples.Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival.Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell linesAccurate outcome prediction in neuroblastoma across independent data sets using a multigene signature.miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples.
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Frank Speleman
@en
Frank Speleman
@nl
type
label
Frank Speleman
@en
Frank Speleman
@nl
prefLabel
Frank Speleman
@en
Frank Speleman
@nl
P31
P496
0000-0002-6628-8559