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Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IVArtificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein TransportDiscovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine PersulfideRapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activationSelective ablation of β-galactosidase-expressing cells with a rationally designed activatable photosensitizer.Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity.Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates.Potential of Enzymomics Methodologies to Characterize Disease-Related Protein Functions.Synthesis of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeabilityA method to rapidly induce organelle-specific molecular activities and membrane tethering.Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).Development of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability.An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase.Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application.Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats.Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy.Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases.Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation.Discovery of Cell-Type-Specific and Disease-Related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism.Boron dipyrromethene as a fluorescent caging group for single-photon uncaging with long-wavelength visible light.Thermal or mechanical stimuli-induced photoluminescence color change of a molecular assembly composed of an amphiphilic anthracene derivative in water.Fluorescence detection of serum albumin with a turnover-based sensor utilizing Kemp elimination reaction.New class of bioluminogenic probe based on bioluminescent enzyme-induced electron transfer: BioLeT.A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques.Unexpected Photo-instability of 2,6-Sulfonamide-Substituted BODIPYs and Its Application to Caged GABA.Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples.Detection of NAD(P)H-dependent enzyme activity by time-domain ratiometry of terbium luminescence.Identification of Lung Inflammation-Related Elevation of Acylamino Acid Releasing Enzyme (APEH) Activity Using an Enzymomics Approach.Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probeICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin!Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxiaDevelopment and validation of an improved diced electrophoresis gel assay cutter-plate system for enzymomics studiesChemical toolbox for 'live' biochemistry to understand enzymatic functions in living systemsMultiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samplesDevelopment of ratiometric carbohydrate sensor based on boron dipyrromethene (BODIPY) scaffoldHigh-throughput single-molecule bioassay using micro-reactor arrays with a concentration gradient of target moleculesDevelopment of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX[Challenges of Young Chemists to Be Global]Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous AcidRed-Shifted Fluorogenic Substrate for Detection of lacZ-Positive Cells in Living Tissue with Single-Cell Resolution
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description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Toru Komatsu
@en
Toru Komatsu
@nl
type
label
Toru Komatsu
@en
Toru Komatsu
@nl
prefLabel
Toru Komatsu
@en
Toru Komatsu
@nl
P31
P496
0000-0002-9268-6964