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Q37331831-3166074D-1D22-4026-B82D-B0CBF9B4EA73
Q37331831-3166074D-1D22-4026-B82D-B0CBF9B4EA73
BestRank
Statement
http://www.wikidata.org/entity/statement/Q37331831-3166074D-1D22-4026-B82D-B0CBF9B4EA73
Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands
P2860
Q37331831-3166074D-1D22-4026-B82D-B0CBF9B4EA73
BestRank
Statement
http://www.wikidata.org/entity/statement/Q37331831-3166074D-1D22-4026-B82D-B0CBF9B4EA73
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Statement
wasDerivedFrom
1feec0cf40ee2519a246a5250807e0106368d79b
P2860
A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.