18-Methoxycoronaridine
(–)-18-Methoxycoronaridine (18-MC) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont. In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamphetamine, nicotine and sucrose. 18-MC is a α3β4 nicotinic antagonist and, in contrast to ibogaine, has no affinity at the α4β2 subtype nor at NMDA-channels nor at the serotonin transporter, and has significantly reduced affinity for sodium channels and for the σ receptor, but retains modest affinity for μ-opioid receptors where it acts as an antagonist, and κ-opioid receptors. The sites of action in the brain include the medial habenula, interped
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18-Methoxycoronaridine
(–)-18-Methoxycoronaridine (18-MC) is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley D. Glick from the Albany Medical College and the chemist Martin E. Kuehne from the University of Vermont. In animal studies it has proved to be effective at reducing self-administration of morphine, cocaine, methamphetamine, nicotine and sucrose. 18-MC is a α3β4 nicotinic antagonist and, in contrast to ibogaine, has no affinity at the α4β2 subtype nor at NMDA-channels nor at the serotonin transporter, and has significantly reduced affinity for sodium channels and for the σ receptor, but retains modest affinity for μ-opioid receptors where it acts as an antagonist, and κ-opioid receptors. The sites of action in the brain include the medial habenula, interped
has abstract
(–)-18-Methoxycoronaridine (18 ...... no effect on NMDA receptors.
@en
18-Methoxycoronaridin (18-MC) ...... lanzenfamilie der Apocynaceae.
@de
CAS number
308123-60-6
FDA UNII code
KX8NQX91Z8
IUPAC name
(–)-18-methoxycoronaridine
@en
PubChem
thumbnail
Wikipage page ID
Wikipage revision ID
740,367,012
ChemSpiderID
legal status
US IND filed 2/9/2014
molecular weight
routes of administration
smiles
O=C[C@@]43c2nc1ccccc1c2CCN5C3[C@H]CCOC
StdInChIKey
DTJQBBHYRQYDEG-YHIIEBRDSA-N
Verifiedfields
verifiedrevid
477,209,336
hypernym
comment
(–)-18-Methoxycoronaridine (18 ...... the medial habenula, interped
@en
18-Methoxycoronaridin (18-MC) ...... lanzenfamilie der Apocynaceae.
@de
label
18-Methoxycoronaridin
@de
18-Methoxycoronaridine
@en