The 1978 Major League Baseball All-Star Game was the 49th midseason exhibition between the all-stars of the American League (AL) and the National League (NL), the two leagues comprising Major League Baseball. The game was played on July 11, 1978 at San Diego Stadium in San Diego, home of the San Diego Padres of the National League. The game resulted in a 7-3 victory for the NL. This was the first All-Star Game to be played in San Diego. It would return in 1992 to be played in the same stadium, though it was renamed Jack Murphy Stadium by that time.