The 1980–81 Georgetown Hoyas men's basketball team represented Georgetown University in the 1980–81 NCAA Division I basketball season. John Thompson, Jr., coached them in his ninth season as head coach. It was the last season in which they played all of their home games at McDonough Gymnasium on the Georgetown campus in Washington, D.C. They were members of the Big East Conference and finished the season with a record of 20-12 overall, 9-5 in Big East play. They advanced to the semifinals of the 1981 Big East Tournament before losing to Syracuse. In the 1981 NCAA Tournament, they lost in the first round to James Madison.