Acestridium colombiense is a species of armored catfish endemic to Colombia. It is only known from the Inírida River, Guainía Department in the east of Colombia. Like all Acestridium species, this is a very slender and elongated fish. Specimens of up to 4.9 centimetres (1.9 in) SL have been recorded. It can most readily distinguished from its congeners by its rather homogenous brown coloration (as opposed to having striped markings) and the very low number of jaw teeth.