Annandale Plantation was a historic cotton plantation and Italianate-style plantation house in what is now the Mannsdale neighborhood of Madison, Mississippi. The house was designed and built for Margaret Louisa Thompson Johnstone, the wealthy widow of John T. Johnstone. Completed during the late 1850s, it was destroyed in a fire during the mid-1920s. A replacement, part of a modern residential development, was later built at the site during the mid-20th century.